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Mori, Toshifumi; Hamers, Robert J.; Pedersen, Joel A.; Cui, Qiang . (2014). Integrated Hamiltonian Sampling: A Simple and Versatile Method for Free Energy Simulations and Conformational Sampling. The Journal of Physical Chemistry B, 118(28), 8210–8220. doi:10.1021/jp501339t 
10.1021/jp501339t